DMSO (Dimethyl Sulfoxide) is a simple
small molecule with amazing chemical, biological and physical characteristics.
DMSO is the resulting by-product from the manufacture of pulp and paper. It has
been used for over 100 years and is harmless when used with the proper
It is sold as a solvent. DMSO is an amazing substance
that has many uses throughout the world. DMSO exhibits very extensive solvent
properties. It can be used as an extraction solvent. Substances possessing a
strongly polar character are generally easily dissolved in DMSO. The solvent
power of DMSO and its power to penetrate the skin should give rise to
precautions in handling this product. It is important to avoid direct contact of
the skin or mucous membranes especially in case of a solution of chemicals and
DMSO. CAUTION: May cause skin irritation. Avoid contact with eyes, skin, and
clothing. Wash thoroughly after handling.
DMSO is recommended as a topical application to reduce
acute swelling due to trauma.
DMSO is a rapidly absorbed
skin penetrant. With the ability to carry other substances through membranes it
acts as an anti-inflammatory agent. DMSO is also a cryoprotective agent that
helps protect frozen tissue. Additionally, DMSO is a potent antioxidant,
scavenging the highly reactive molecules that contribute to disease and aging,
known as free radicals.
It has been found that medications dissolved in DMSO
retain their therapeutic activity and their specific properties over a longer
period of time. It maintains and multiplies the activity of many drugs. Allergic
reactions are diminished by the actions of DMSO.
Other Properties of DMSO
Reduces pain and swelling
Acts as an antioxidant
Forms a water molecule in the body
which is easily excreted
Acts as a free radical scavenger
May reduce the pain and swelling of
Has an odor that can be dissipated with
aloe and mint flavor
May be used for insect bites, acne,
neuritis, neuralgia and shingles
Pyrogen Free, Acetone Free; 99.9%
Laboratory Tested Solvent
This product is intended for use as a mild solvent
only. The choice of the process used in the various applications is the
sole responsibility of the user. Please consult with your veterinarian as
to the proper use of DMSO.
DMSO (dimethyl sulfoxide) Gel is recommended as a
topical application to reduce acute swelling due to trauma.
Off-Label Administration and Dosage:
Recommended as a topical application to reduce swelling
due to trauma.
CONSULT YOUR PHYSICIAN OR VETERINARIAN BEFORE USING THIS
PRODUCT ON A PERSON OR ANIMAL. Any use other than as a solvent is
considered off-label use.
DMSO Gel is to be administered topically to the skin
over the affected area.
Dogs - Liberal application should be administered three
to four times daily. Total daily dosage should not exceed 20 g. Total duration
of therapy should not exceed 14 days.
Horses - Liberal application should be administered two
to three times daily. Total daily dosage should not exceed 100 g. Total duration
of therapy should not exceed 30 days.
In general, adverse reactions are local,
and while they may prove to be annoying to some patients, they are usually not
of a serious nature. Upon topical application, an occasionally animal may
develop transient erythema, associated with local “burning” or “smarting”. Even
when erythema or vesiculation occurs, they are self-limiting reversible states,
and not necessarily an indication to discontinue medication. Dryness of the skin
and an oyster-like breath odor have been reported. These effects are temporary
and are not considered to be of serious consequence. Changes in the refractive
index of the lens of the eye and nuclear cataracts have been observed in
animals, with the use of this drug. This appears to be related to dosage and
duration of therapy.
Precaution and Contraindications:
Contact between DMSO Gel and the skin should be avoided.
Rubber gloves should be worn while applying this drug. Forceps and swabs may be
used to facilitate application. If absorbed through the skin, DMSO Gel will
cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness,
sensations of warmth, burning, irritation, itching and mild erythematous
localized or generalized dermatitis have been reported in some persons following
exposure to DMSO Gel. Treatment of such side effects is symptomatic. Consult a
physician immediately if adverse effects appear.
DMSO Gel may mask certain disease signs such as seen in
fractures, etc.; this does not obviate the need for specific therapy in such
Since DMSO Gel effectively alters the biologic membrane,
it will in some cases facilitate the systemic absorption of other topically
applied drugs and may have a potentiating effect on drugs administered
DMSO Gel should be judiciously used when administered in
conjunction with other pharmaceutical preparations, especially those affecting
the cardiovascular and central nervous systems.
DMSO Gel may enhance the absorption of other materials
into the skin. The veterinarian should make certain that other medications are
not present prior to its application.
Keep DMSO Gel out of the reach of children.
DMSO Gel is recommended for topical application only.
DO NOT ADMINISTER BY ANY OTHER ROUTE.
DMSO Gel should not be used under occlusive dressings.
DMSO Gel is contraindicated in horses and dogs intended
for breeding purposes.
DMSO Gel is a potent solvent and may have a deleterious
effect on fabrics, plastics and other materials. Care should be taken to prevent
physical contact with DMSO Gel.
DMSO Gel should not be administered to horses that are
to be slaughtered for food.
CAUTION: HYGROSCOPIC. CLOSE CAP TIGHTLY AFTER USE. AVOID
FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DMSO GEL, RUBBER GLOVES SHOULD
BE WORN WHEN APPLYING THIS PRODUCT.