Denosyl and Marin support the liver through differing actions and may be used
individually or in combination. Denamarin is one such patented combination liver
supplement for dogs and cats containing both pure and stabilized S-Adenosylmethionine
(SAMe) and silybin-phosphatidylcholine complex. Both SAMe and silybin have been
shown to markedly increase levels of antioxidants formed when cats and dogs metabolize
it. Silybin also helps with liver cell regeneration and enhances levels of glutathione,
the liver’s major “detoxifying” agent.
Denamarin has no known side-effects.
Directions for Use:
Tablets should be given on an empty stomach at least one hour before a meal
for optimal absorption ( overnight fast preferred). For owners who find it difficult
to administer tablets to their pets, Denamarin tablets may be disguised in a
small bite of food. The number of tablets administered may be gradually reduced,
or increased, at any time at the recommendation of your veterinarian.
35-65 lbs = 1 tablet per day
66-120 lbs = 2 tablets per day
Over 120 lbs Over = 3 tablets per day
Store in a cool dry place. Keep tablets in original blister pack until used.
Tablets are sensitive to moisture and extreme heat and should not be split or
How does Denamarin work?
When liver function is compromised, the exact cause can often be difficult
to determine. Supporting the liver, regardless of the cause, is essential to
keep it working properly.
Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has
been shown to markedly increase liver levels of glutathione,1,2 an important
compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin
has also been shown to help protect liver cells from cell death3,4 and may help
cell repair and regeneration.5
Denamarin also helps support your pet’s liver through the administration
of silybin. Silybin is an active part of an extract from milk thistle, known
as silymarin, and has been shown to support liver function by helping maintain
a healthy oxidative balance.
The new chewable tablets of Denamarin allow dogs to receive SAMe and silybin
in a tasty treat, eliminating the need to "pill" your dog daily. Additionally,
the chewable tablets allow for quicker uptake of the SAMe and less variability
between dogs when compared to enteric-coated tablets.
While best known for supporting the liver in dogs and cats Denamarin also
has a place in supporting brain health. Research is looking into dog aging and
associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal
fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form
to help with brain health and act as a neuroprotector. Denamarin also provides
a bioavailable form of silybin which supports oxidative balance.
Denamarin has no known serious side-effects. Your veterinarian can evaluate
the length of support needed through follow-up examinations, blood work, and/or
other laboratory work. At home, watch for improvements in your pet’s attitude,
appetite, and activity level.