Coenzyme Q, also known as ubiquinone, is a lipid-soluble compound that inhabits the inside of inner mitochondrial membranes. CoQ functions as a cofactor in several enzyme systems related to energy conversion and is a vital catalyst to energy production at the cellular level. As such, it is essential for human and animal life to exist.
The mitochondria are called the "powerhouses" of the cell. Without them the cells would be unable to extract significant amounts of energy from the nutrients and oxygen, and as a consequence essentially all cellular functions would cease. Mitochondria are present in all portions of the cytoplasm but the number per cell varies from less than a hundred to several thousand, depending upon the amount of energy required by each cell. They are abundant in skeletal muscle cells and very abundant in myocardial cells. Because of the huge energy needs of the myocardial cells, a deficiency of CoQ could have a particularly severe effect on myocardial function.
Coenzyme Q is generally accepted in biochemistry as a natural or intrinsic component of electron transfer processes of respiration and coupled oxidative phosphorylation. The response to CoQ supplementation over time is acceptable in biochemistry for a nutrient in contrast to the almost immediate responses of drugs that act by pharmacologic mechanisms. CoQ has been demonstrated to be effective and safe with no adverse effects reported in any human or animal studies.
The very nature of coenzyme Q is to become oxidized during the transfer of energy, and to be recharged by chemical reduction. This continuous process can eventually take its toll by oxidizing small amounts of CoQ past the point of no return into degraded products that cannot be recharged.
This aspect of coenzyme Q is extremely important because exposure to oxygen in the air, light and heat during commercial production of CoQ can cause extensive oxidation. If not protected from the relentless exposure to oxygen during its manufacture, distribution and storage, CoQ can be degraded past the point of no return, thereby losing its effectiveness.
CoMal Q is stabilized using Nutramax Laboratories exclusive Antioxidant Protection System. This proprietary system uses the very antioxidant protectors used by plants to protect their forms of coenzyme Q from the ravages of oxygen. Importantly, these protectors are oil-soluble just like coenzyme Q thus affording immediate protection to CoMal Q.
Emulsification is another important factor in CoQ manufacture. Research has shown that emulsified CoQ at 30 mg per day increased serum levels 80% in 4 weeks, and that 30 mg of emulsified CoQ oil proved to be as effective as 90 to 100 mg of dry powder CoQ in elevating serum levels. Another study of oil and dry form preparation increasing CoQ blood levels to 2.7 times preadministration levels in 4 days at a dose of 60 mg per day.
CoMal Q is emulsified using Nutramax Laboratories state of the art emulsification process without detergents or water. The process uses nature-identical compounds found in our foods and bodies with the most stable oil known to food science.
Recommendation for Dogs, Cats and Horse
As a supplement, one (1) to three (3) capsules daily according to the chart below, or as directed by your veterinarian. Soft gel capsules may be administered whole or punctured and the contents squeezed over food. Each capsule contains 30mg Coenzyme Q10.
|PETS UNDER 30lbs
||One (1) capsule daily
|PETS 30 to 60lbs
||Two (2) capsules daily
|PETS OVER 60lbs
||Three (3) capsules daily
||Six (6) to Nine (9) capsules daily
Once improvement is noted, long-term administration may be reduced to every other day.
Medium chain triglycerides, monoglycerides, Coenzyme Q10, rosemary, sage, gelatin, purified water, titanium dioxide, FD&C red #3, FD&C yellow #5, sodium lauryl sulfate, and FD&C blue #1