Program Flavor Tabs 6 pk Dog 46-90 lbs

PROGRAM^® FLAVOR TABS^™ AND CAPSTAR^® FLEA MANAGEMENT SYSTEM

Novartis

(LUFENURON) / (NITENPYRAM)

Supplemental Product Information

This insert describes the concurrent use of PROGRAM^® (lufenuron) Flavor Tabs^™ and CAPSTAR^® (nitenpyram) Tablets for the management of fleas on dogs and puppies. Please read the insert contained in each package for complete information on the individual products prior to dosing.

Warnings

Not for human use. Keep this and all drugs out of reach of children.

Directions

In dogs and puppies the concurrent use of PROGRAM Flavor Tabs and CAPSTAR Tablets is indicated to kill adult fleas and prevent eggs from hatching. The effects of PROGRAM Flavor Tabs, which prevent and control flea populations, and CAPSTAR Tablets, which treat flea infestations, are combined to provide a FLEA MANAGEMENT SYSTEM.

Step 1: Prevention and Control

Give PROGRAM Flavor Tabs once per month to prevent and control flea populations. PROGRAM Flavor Tabs contain lufenuron. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. If a dog currently has a flea infestation, more rapid relief can be accomplished by adding CAPSTAR to the treatment as follows.

Step 2: Kill Adult Fleas

If your pet currently has a flea infestation, use CAPSTAR Tablets to kill adult fleas. CAPSTAR Tablets contain nitenpyram and are effective for the treatment of flea infestations. Nitenpyram starts killing adult fleas within 30 minutes of administration.

· Administer CAPSTAR Tablets once per week until adult fleas are no longer observed.

· For a severe flea infestation, administer CAPSTAR Tablets twice per week until adult fleas are no longer observed.

· Additional CAPSTAR Tablets may be administered as needed to kill the occasional adult flea picked up from infested environments.

· It is important to treat all cats (see below) and dogs in the household. Fleas can reproduce on untreated pets and allow infestations to persist.

Dosage

The combination of PROGRAM Flavor Tabs and CAPSTAR Tablets should be administered according to the following schedule. Weigh the dog prior to administration to ensure proper dosage. Do not administer to dogs under 2 pounds.

Recommended Dosage Schedule

* If adult fleas are seen

**Dogs over 90 lbs. are provided the appropriate combination of PROGRAM Flavor Tabs.

Adverse Reactions

The following adverse reactions have been reported in dogs after giving PROGRAM Flavor Tabs: vomiting, depression/lethargy, pruritus (itchy, scratchy skin), urticaria (wheals, hives), diarrhea, anorexia (loss of appetite), and skin congestion (red skin).

Other Information

The safety of the concurrent use of lufenuron, the active ingredient in PROGRAM Flavor Tabs and CAPSTAR Tablets has not been evaluated in puppies less than 11 weeks old.

Flea Infestations on Dogs

In addition to the common nuisance irritations associated with infestations, fleas can be responsible for skin conditions in the dog such as flea allergy dermatitis. Fleas also transmit other parasites, including tapeworms. The control of flea infestations is important to the pet's health and reduces the problems associated with these parasites.

PROGRAM Flavor Tabs break the flea life cycle by inhibiting egg development. CAPSTAR Tablets kill adult fleas on the dog. The concurrent use of these two products provides an effective flea management system.

The following diagram illustrates the flea's life cycle and where the combination of PROGRAM Flavor Tabs and CAPSTAR Tablets work:

Life Cycle of the Flea

A single female flea may produce up to 2,000 eggs over her lifetime. Eggs hatch and can develop into adults within only three weeks. Adult female fleas feed by ingesting blood from the pet and subsequently lay eggs, which drop off the pet's coat. Within days, larvae hatch from the eggs and live undetected in the pet's surroundings, such as the carpet and bedding. Flea larvae spin a cocoon, and, when appropriately stimulated, a young adult flea emerges and jumps onto the pet to continue the life cycle.

After reading this insert, if you have any questions about the concurrent use of PROGRAM Flavor Tabs and CAPSTAR Tablets in your dogs, please call Novartis Animal Health Veterinary Product Support at 1 (800)-332-2761.

Storage Conditions

Store PROGRAM Flavor Tabs and CAPSTAR as described on the individual product inserts.